Figure 17. Summary of SAR Performed on the Quinolinone Scaffold (39 analogs, 28S/11P).

Figure 17Summary of SAR Performed on the Quinolinone Scaffold (39 analogs, 28S/11P)

SAR analysis of the quinolinone scaffold. A leaving group at the 4-position, a nitro group, and N-substitution with small aliphatic groups were essential for activity and selectivity

From: Discovery of Inhibitors of Anti-Apoptotic Protein A1

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