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Bond M, Rogers G, Peters J, et al. The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model. Southampton (UK): NIHR Journals Library; 2012 Apr. (Health Technology Assessment, No. 16.21.)

Cover of The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model

The Effectiveness and Cost-Effectiveness of Donepezil, Galantamine, Rivastigmine and Memantine for the Treatment of Alzheimer's Disease (Review of Technology Appraisal No. 111): A Systematic Review and Economic Model.

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Appendix 2Literature search strategies

Clinical effectiveness search strategy

The MEDLINE search strategy below was translated and run in:

DatabaseSearch date
MEDLINE (Ovid) and MEDLINE In-Process & Other Non-Indexed Citations: 1950 to present16 November 2009
EMBASE (Ovid): 1980 to 2009 week 46
PsycINFO (Ovid): 2002 to November week 2 2009
CCTR: 2009 Issue 413 November 2009
CDSR: 2009 Issue 4
CRD databases: NHS EED, HTA, DARE16 November 2009
ISI Web of Science: SCI
ISI Web of Science: CPCI
BIOSIS – via ISI Web of Science

CCTR, Cochrane controlled trials reports; CDSR, Cochrane Database of Systematic Reviews; CPCI, Conference Proceedings Citation Index; DARE, Database of Abstracts of Reviews of Effects; HTA, Health Technology Assessment database; SCI, Science Citation Index.

All searches were then rerun on 31 March 2010.

MEDLINE Ovid 1950 to present

Search date: 16 November 2009; rerun search date 31 March 2010.

  1. Alzheimer Disease/
  2. alzheimer*.tw.
  3. 1 or 2
  4. ebixa.mp.
  5. axura.mp.
  6. namenda*.mp.
  7. or/4-8
  8. galantamin*.mp.
  9. galanthamine.mp.
  10. Epigalanthamin.mp.
  11. Jilkon*.mp.
  12. Lycoremin*.mp.
  13. Nivalin*.mp.
  14. Razadyne*.mp.
  15. Reminyl*.mp.
  16. or/10-18
  17. donezepil*.mp.
  18. aricept*.mp.
  19. Memac*.mp.
  20. Memorit*.mp.
  21. Eranz*.mp.
  22. or/20-25
  23. rivastigmin*.mp.
  24. exelon*.mp.
  25. prometax*.mp.
  26. or/27-29
  27. 30 or 26 or 19 or 9
  28. 3 and 31
  29. Randomized controlled trial.pt.
  30. randomized controlled trial/
  31. (random$or placebo$).ti,ab,sh.
  32. ((singl$or double$or triple$or treble$) and (blind$or mask$)).tw,sh.
  33. or/33-36
  34. clinical trial/
  35. “controlled clinical trial”.pt.
  36. (retraction of publication or retracted publication).pt.
  37. 37 or 38 or 39 or 40
  38. 32 and 41
  39. (animals not humans).sh.
  40. 42 not 43
  41. limit 44 to (english language and yr = “2004 -Current”)

Cost-effectiveness search strategy

This following MEDLINE search strategy was translated and run in:

DatabaseSearch date
MEDLINE (Ovid) and MEDLINE In-Process & Other Non-Indexed Citation: 1950 to present5 February 2010
EMBASE (Ovid): 1980 to 2009 week 46
PsycINFO (Ovid): 2002 to November week 2 20094 February 2010
CCTR: 2009 Issue 4
CDSR: 2009 Issue 413 November 2009
CRD databases: NHS EED, HTA, DARE5 February 2010
ISI Web of Science: SCI
ISI Web of Science: CPCI
BIOSIS – via ISI Web of Science
EconLit

CCTR, Cochrane controlled trials reports; CDSR, Cochrane Database of Systematic Reviews; CPCI, Conference Proceedings Citation Index; DARE, Database of Abstracts of Reviews of Effects; HTA, Health Technology Assessment database; SCI, Science Citation Index.

MEDLINE Ovid 1950 to present

Searched 4 February 2010.

  1. exp Alzheimer Disease/
  2. alzheimer$.ti,ab.
  3. 1 or 2
  4. Economics, Medical/
  5. Economics, Nursing/
  6. exp economics, hospital/
  7. economics pharmaceutical/
  8. ec.fs.
  9. exp “Costs and Cost Analysis”/
  10. exp Cost-benefit Analysis/
  11. “Value of Life”/
  12. exp Models, Economic/
  13. exp “Fees and Charges”/
  14. Resource Allocation/
  15. exp Budgets/
  16. budget*.tw.
  17. (economic$or price$or pricing or financ$or fee$or pharmacoeconomic$or pharma economic$).tw.
  18. (expenditure$not energy).tw.
  19. (value$5 adj2 (money or monetary or life or lives or cost$2)).tw.
  20. (economic adj2 burden).tw.
  21. (resource$2 adj2 (use* or utili* or allocat*)).tw.
  22. (cost$2 adj2 (benefit$or consequence* or analys* or saving* or breakdown* or lowering or estimat* or variable* or allocation* or control* or illness* or affordable* or instrument* or technolog* or fee* or charge$2 or utilit$or minim$or effective$or effective* or efficac*)).ab.
  23. cost.ti.
  24. 22 or 23
  25. or/4-24
  26. ebixa.mp.
  27. axura.mp.
  28. namenda*.mp.
  29. galantamin*.mp.
  30. galanthamine.mp.
  31. Epigalanthamin.mp.
  32. Jilkon*.mp.
  33. Lycoremin*.mp.
  34. Nivalin*.mp.
  35. Razadyne*.mp.
  36. Reminyl*.mp.
  37. donezepil*.mp.
  38. aricept*.mp.
  39. Memac*.mp.
  40. Memorit*.mp.
  41. Eranz*.mp.
  42. rivastigmin*.mp.
  43. exelon*.mp.
  44. prometax*.mp.
  45. or/26-48
  46. 3 and 25 and 49
  47. limit 50 to (english language and yr = “2004 -Current”)

Quality of life and utilities search strategy

The following MEDLINE search strategy was translated and run in:

DatabaseSearch date
MEDLINE (Ovid) and MEDLINE In-Process & Other Non-Indexed Citations: 1950 to present6 January 2010
EMBASE (Ovid): 1980 to 2009 week 465 February 2010
PsycINFO (Ovid): 2002 to November week 2 20094 February 2010
CCTR: 2009 Issue 4
CDSR: 2009 Issue 413 November 2009
CRD databases: NHS EED, HTA, DARE5 February 2010
ISI Web of Science: SCI
ISI Web of Science: CPCI
BIOSIS – via ISI Web of Science
EconLit

CCTR, Cochrane controlled trials reports; CDSR, Cochrane Database of Systematic Reviews; CPCI, Conference Proceedings Citation Index; DARE, Database of Abstracts of Reviews of Effects; HTA, Health Technology Assessment database; SCI, Science Citation Index.

  1. “Quality of Life”/
  2. “Value of Life”/
  3. ((qualit$3 or value) adj2 life).tw.
  4. quality-adjusted life years/
  5. quality adjusted.tw.
  6. (qaly* or qald* or qale* or qtime* or qualy).tw.
  7. sickness impact profile/
  8. (disabilit$3 adj2 life).tw.
  9. daly.tw.
  10. Health Status Indicators/
  11. (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirstysix or shortform thirty six or short form thirty six or short form thirtysix or short form thirty six).tw.
  12. (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
  13. (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve of sftwelve or shortform twelve or short form twelve).tw.
  14. (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.
  15. (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty of sftwenty or shortform twenty of short form twenty).tw.
  16. (euroqol or euro qol or eq5d or eq 5d).tw.
  17. (hql or hqol or qol or hrqol).tw.
  18. (hye or hyes).tw.
  19. health$year$equivalent$.tw.
  20. health utilit* or utilities or utility value*).tw.
  21. hui$1.tw.
  22. disutil$.tw.
  23. rosser.tw.
  24. (quality adj3 well).tw.
  25. quality of wellbeing.tw.
  26. qwb.tw.
  27. willingness to pay.tw.
  28. standard gamble$.tw.
  29. (time trade off or time tradeoff or tto).tw.
  30. (health adj3 (utilit$3 or value$2 or preference$2)).tw.
  31. (visual analog$3 scale or VAS).tw.
  32. (health adj2 (utilit$3 or value$2 or preference$2)).tw.
  33. patient preference$2.tw.
  34. or/1-33
  35. mini mental state exam$.ti,ab.
  36. ((mmse or mmmse) adj5 alzheimer*).ti,ab.
  37. modified mmse.ti,ab.
  38. alzheimer$disease assessment scale$.ti,ab.
  39. adas.ti,ab.
  40. adas cog$.ti,ab.
  41. cibic$.ti,ab.
  42. progressive deterioration scale$.ti,ab.
  43. (pds adj5 alzheimer*).ti,ab.
  44. (clinical global impression of change or CGIC).tw.
  45. clinic* interview based impression of change.tw.
  46. (CDR or clinical dementia rating).tw.
  47. alzheimer$.tw.
  48. Alzheimer Disease/
  49. 47 or 48
  50. 34 and 49
  51. (cognitive adj (scale* or rating or rate)).tw.
  52. 49 and 51
  53. or/35-46
  54. 49 and 53
  55. 50 or 52 or 54
  56. limit 55 to (english language and yr = “2004 -Current”)

Additional searches for economic modelling parameters

The following MEDLINE search strategy was translated and run in:

DatabasesSearch date
Ovid MEDLINE: 1950 to present7 January 2010
Ovid MEDLINE In-Process & Other Non-Indexed Citations
BIOSIS via Web of Science8 January 2010
EMBASE 1980 to 2009 week 467 January 2010
ISI Web of Science: SCI-EXPANDED8 January 2010
ISI Web of Science: CPCI-S
NHS EED via CRD databases
EconLit via First Search

CPCI-S, Conference Proceedings Citation Index-Science; SCI-EXPANDED, Science Citation Index Expanded.

Ovid MEDLINE(R) 1950 to October week 2 2007

Searched: 24 October 2007.

  1. Alzheimer Disease/
  2. alzheimer$.tw.
  3. 1 or 2
  4. exp Models, Economic/
  5. *Models, Theoretical/
  6. *Models, Organizational/
  7. economic model$.ti,ab.
  8. Markov Chains/
  9. markov$.ti,ab.
  10. Monte Carlo Method/
  11. monte carlo.ti,ab.
  12. exp Decision Theory/
  13. (decision$adj2 (tree$or analy$or model$)).ti,ab.
  14. or/4-13
  15. 3 and 14
  16. limit 15 to (english language and yr = “2004 -Current”)

Additional searches for dementia model parameter, quality of life and utilities

The following MEDLINE search strategy was translated and run in:

DatabasesSearch date
Ovid MEDLINE 1950 to present19 February 2010
Ovid MEDLINE In-Process & Other Non-Indexed Citations
EMBASE – 1980 to 2009 week 46
PsycINFO (Ovid): 2002 to November week 2 2009
NHS EED via CRD databases

Ovid MEDLINE(R) 1950 to October week 2 2007

Search date: 19 February 2010.

  1. Dementia/ (29,095)
  2. *Dementia/ (22,077)
  3. dementia.ti. (22,047)
  4. 2 or 3 (30,348)
  5. exp Models, Economic/ (6944)
  6. (economic next model* or markov* or monte next carlo).ti. (1847)
  7. (economic next model* or markov* or monte next carlo).ab. (7968)
  8. or/5–7 (14,883)
  9. 4 and 8 (28)
  10. 1 and 8 (29)
  11. 9 or 10 (33)
  12. “Quality of Life”/ (79,428)
  13. (quality adj2 life).ti. (26,019)
  14. (quality adj2 life).ab. (87,761)
  15. quality-adjusted life years/ (4171)
  16. (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirstysix or shortform thirty six or short form thirty six or short form thirtysix or short form thirty six).tw. (9883)
  17. (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (1012)
  18. (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve of sftwelve or shortform twelve or short form twelve).tw. (1382)
  19. (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (19)
  20. (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty of sftwenty or shortform twenty of short form twenty).tw. (288)
  21. (euroqol or euro qol or eq5d or eq 5d).tw. (1832)
  22. utilit*.ti. (12,510)
  23. or/12-22 (141,512)
  24. 4 and 23 (1064)
  25. 9 or 24 (1085)
  26. limit 25 to english language (905)
  27. from 26 keep 1-905 (905)

Additional citation searching and ad hoc searches were performed for model parameters.

© 2012, Crown Copyright.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK98909

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