Figure 13.37. The JAK/STAT pathway.

Figure 13.37The JAK/STAT pathway

The STAT proteins are transcription factors that contain SH2 domains that mediate their binding to phosphotyrosine-containing sequences. In unstimulated cells, STAT proteins are inactive in the cytosol. Stimulation of cytokine receptors leads to the binding of STAT proteins, where they are phosphorylated by the receptor-associated JAK protein-tyrosine kinases. The phosphorylated STAT proteins then dimerize and translocate to the nucleus, where they activate the transcription of target genes.

From: Pathways of Intracellular Signal Transduction

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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