Figure 7.32. Structure of a GPI anchor.

Figure 7.32Structure of a GPI anchor

The GPI anchor, attached to the C terminus, anchors the protein in the plasma membrane. The anchor is joined to the C-terminal amino acid by an ethanolamine, which is linked to an oligosaccharide that consists of mannose, N-acetylgalactosamine, and glucosamine residues. The oligosaccharide is in turn joined to the inositol head group of phosphatidylinositol. The two fatty acid chains of the lipid are embedded in the plasma membrane. The GPI anchor shown here is that of a rat protein, Thy-1.

From: Protein Folding and Processing

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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