NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Cover of Maintaining Research Integrity

Maintaining Research Integrity

A Systematic Review of the Role of the Institutional Review Board in Managing Conflict of Interest

Evidence-based Synthesis Program

Investigators: , MD, PhD, , MD, , BA, , BS, and , PhD.

Evidence-based Synthesis Program (ESP) Center, West Los Angeles VA Medical Center
Washington (DC): Department of Veterans Affairs (US); .

Excerpt

Ethical integrity in the conduct of health care research is essential for maintaining the public trust and support of such activities. Institutional Review Boards (IRBs) play a critical role in maintaining the ethical integrity of research by reviewing research protocols to ensure, among other things, that research participants receive safe and ethical treatment and provide informed consent, and that the potential for a conflict of interest is minimized. The purpose of this review was to catalog the literature on issues pertaining to IRBs, to identify the issue with the greatest number of published studies which might inform VA policy, and to assess the evidence regarding that issue, which were conflict of interest policies and the activities of the IRB.

Contents

Prepared for: Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service, Washington, DC 20420. Prepared by: Evidence-based Synthesis Program (ESP) Center, West Los Angeles VA Medical Center, Los Angeles, CA, Paul G. Shekelle, MD, PhD, Director.

Suggested citation:

Shekelle PG, Ruelaz A, Miake-Lye IM, Beroes JM, Newberry S. Maintaining Research Integrity: A Systematic Review of the Role of the Institutional Review Board in Managing Conflict of Interest, VA-ESP Project #05-226; 2012.

This report is based on research conducted by the Evidence-based Synthesis Program (ESP) Center located at the West Los Angeles VA Medical Center, Los Angeles, CA funded by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Quality Enhancement Research Initiative. The findings and conclusions in this document are those of the author(s) who are responsible for its contents; the findings and conclusions do not necessarily represent the views of the Department of Veterans Affairs or the United States government. Therefore, no statement in this article should be construed as an official position of the Department of Veterans Affairs. No investigators have any affiliations or financial involvement (e.g., employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties) that conflict with material presented in the report.

Bookshelf ID: NBK98419PMID: 22787689

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (914K)

Other titles in this collection

Related information

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...