Figure 3. Aberrant neurogenesis in experimental mTLE.

Figure 3Aberrant neurogenesis in experimental mTLE

Schematic of the intact adult dentate gyrus (A) with a DGC progenitor in the subgranular zone (SGZ) giving rise to immature DGCs (arrows). In the epileptic dentate gyrus (B), mossy fiber sprouting does not come from mature DGCs (1), but instead arises from developing or newborn DGCs (2), which also display HBDs (3), ectopic migration (4), and possibly axonal sprouting onto DGCs with HBDs or that are ectopic (5). Some newborn DGCs appear to integrate normally and may restore inhibition (6). IML, inner molecular layer; GCL, granule cell layer.

From: Neurogenesis and Epilepsy

Cover of Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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