This figure shows the effect size for each study in a forest plot for all monotherapy vs combined therapy studies for the outcome of response for other antidepressants and non-pharmacological agents. All studies show a relative risk that crosses 1 (no difference) between groups.

Figure 8Forest plot of monotherapy versus combined therapies for the outcome of response for all interventions but augmenting agents

Abbreviations: B = Beck Depression Inventory; BUP = bupropion; CBT = cognitive behavioral therapy; CIT = citalopram; CM = clomipramine; DES = desipramine; DSM-IV = the Diagnostic and Statistical Manual of Mental Disorders – 4th edition; FLX = fluoxetine; H-17 = Hamilton Depression Rating Scale – 17 item; H-21 = Hamilton Depression Rating Scale – 21 item; IPT = interpersonal therapy; Med = medication; PBO = placebo; Q-16 = Quick Inventory of Depressive Symptoms Self Report (16); SER = sertraline; SSRI = selective serotonin reuptake inhibitors; VEN = venlafaxine

* Represent STAR*D studies.

From: Results

Cover of Treatment for Depression After Unsatisfactory Response to SSRIs
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Santaguida PL, MacQueen G, Keshavarz H, et al.

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