FIGURE 6-13. Illustration of the relationships between speed of cure on two different antibiotics (A vs. B) and the time that clinical assessment is made in typical clinical trials.

FIGURE 6-13Illustration of the relationships between speed of cure on two different antibiotics (A vs. B) and the time that clinical assessment is made in typical clinical trials

This illustrates why equivalence studies are unlikely to show differences between two antibiotics that illustrate different rates of killing, such as a concentration-dependent FQ versus a time-dependent macrolide or beta-lactam. Serial cultures will clarify these early and more rapid cure patterns and illustrate differences between the antibiotics. Adapted with permission from Dr. C.H. Nightingale, Hartford, CT.

From: 6, Emerging Tools and Technology for Countering Resistance

Cover of The Resistance Phenomenon in Microbes and Infectious Disease Vectors
The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary.
Institute of Medicine (US) Forum on Emerging Infections; Knobler SL, Lemon SM, Najafi M, et al., editors.
Washington (DC): National Academies Press (US); 2003.
Copyright © 2003, National Academy of Sciences.

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