Table 4.

Types of Classic Lissencephaly and Associated Genes

Lissencephaly Type (OMIM#)Gene (OMIM#)Mode of Inheritance
LIS1 (607432)PAFAH1B1 (601545)Autosomal recessive
LIS2 (257320)RELN (600514)Autosomal recessive
LIS3 (611603)TUBA1A (602529)Autosomal recessive
LIS4 (614019)NDE1 (609949)Autosomal recessive
LISX1 (300067)DCX (300121)X linked
LISX2 (300215)ARX (300382)X linked

From: Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders

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