Histological Classification of Hematopoietic Tumors of Domestic Animals compared with the WHO Classification of Human Hematopoietic Tumors (VALLI et al. 2002)

Histological Classification of Hematopoietic Tumors of Domestic AnimalsWHO Classification of Human Hematopoietic Tumors
Tumors of Lymphoid System
1. B-Cell Lymphoid Neoplasms B-Cell Neoplasms
 1.1 Precursor B-cell neoplasmsPrecursor B-cell neoplasm
  1.1.1 B-cell lymphoblastic leukemia/lymphoma Precursor B-lymphoblastic leukaemia/lymphoma
 1.2 Mature B-cell neoplasmsMature (peripheral) B-cell neoplasms
  1.2.1 B-cell chronic lymphocytic leukemia/lymphoma B-cell chronic lymphocytic leukaemia/small lymphocytic lymphoma
  1.2.2 B-cell lymphocytic lymphoma intermediate type (LLI) B-cell prolymphocytic leukaemia
  1.2.3 Lymphoplasmacytic lymphoma (LPL) Lymphoplasmacytic lymphoma
  1.2.4 Follicular lymphomas Follicular lymphoma
   1.2.4.1 Mantle cell lymphoma (MCL) Mantle cell lymphoma
   1.2.4.2 Follicular center cell lymphoma I Follicular lymphoma
   1.2.4.3 Follicular center cell lymphoma II Grade II, 6–15 centroblasts/hpf
   1.2.4.4 Follicular center cell lymphoma III Grade III, > 15 centroblasts/hpf
   1.2.4.5 Nodal marginal zone lymphoma Nodal marginal zone B-cell lymphoma of MALT type
   1.2.4.6 Splenic marginal zone lymphoma Splenic marginal zone B-cell lymphoma (+/− villous lymphocytes)
  1.2.5 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)Extranodal marginal zone B-cell lymphoma of MALT type
  1.2.6 Hairy cell leukemiaHairy cell leukaemia
  1.2.7 Plasmacytic tumorsPlasma cell myeloma variants
   1.2.7.1 Indolent plasmacytoma Extramedullary plasmacytoma
   1.2.7.2 Anaplastic plasmacytoma Indolent myeloma
   1.2.7.3 Plasma cell myelomaPlasma cell myeloma/plasmacytoma
  1.2.8 Large B-cell lymphomasDiffuse large B-cell lymphoma morphological var.
   1.2.8.1 T-cell-rich B-cell lymphoma T-cell/histiocyte-rich (diffuse large B-cell)
   1.2.8.2 Large cell immunoblastic lymphoma Immunoblastic
   1.2.8.3 Diffuse large B-cell (noncleaved, cleaved) lymphoma Diffuse large B-cell lymphoma
   1.2.8.4 Thymic B-cell lymphoma (mediastinal B) Mediastinal (thymic) large B-cell lymphoma
   1.2.8.5 Intravascular large B-cell lymphoma Intravascular large B-cell lymphoma
  1.2.9 Burkitt-type lymphoma Burkitt lymphoma/Burkitt cell leukaemia
   1.2.9.1 High-grade B-cell lymphoma, Burkitt-like Burkitt lymphoma morphological variants Burkitt-like
2. T-Cell and NK-cell Lymphoid Neoplasms T and NK-Cell Neoplasms
2.1 Precursor T-cell neoplasmsPrecursor T-cell neoplasm
 2.1.1 T-cell lymphoblastic leukemia/lymphomaPrecursor T-lymphoblastic lymphoma/leukaemia
2.2 Mature T-cell and NK-cell neoplasmsMature (peripheral) T-cell neoplasms
 2.2.1 Large granular lymphoproliferative disorders (LGL)
  2.2.1.1 T-cell chronic lymphocytic leukemia T-cell prolymphocytic leukaemias
  2.2.1.2 T-cell LGL lymphoma/leukemia T-cell granular lymphocytic leukaemia
  2.2.1.3 NK-cell chronic lymphocytic leukemia Aggressive NK-cell leukaemia Extranodal NK/T-cell lymphoma, nasal type Hepatosplenic T-cell lymphoma
 2.2.2 Cutaneous T-cell neoplasms
  2.2.2.1 Cutaneous epitheliotropic lymphoma (CEL)
   2.2.2.1.1 CEL, mycosis fungoides type Mycosis fungoides/Sezary syndrome
   2.2.2.1.2 CEL, Pagetoid reticulosis type Pagetoid reticulosis
 Subcutaneous panniculitis-like T-cell lymphoma
  2.2.2.2 Cutaneous nonepitheliotropic lymphomaPeripheral T-cell neoplasms, primary extranodal
 2.2.3 Extranodal/peripheral T-cell lymphoma (PTCL)Lymphomatoid papulosis
  2.2.3.1 PTCL, mixed lymphoid type
  2.2.3.2 PTCL, mixed inflammatory typeAdult T-cell lymphoma/leukaemia (HTLV-1+)
 2.2.4 Adult T-cell-like lymphoma/leukemiaAngioimmunoblastic T-cell lymphoma
 2.2.5 Angioimmunoblastic lymphoma (AILD)
 2.2.6 Angiotropic lymphoma
  2.2.6.1 Angiocentric lymphoma
  2.2.6.2 Angioinvasive lymphomaEnteropahty-type T-cell lymphoma
 2.2.7 Intestinal T-cell lymphomaAnaplastic large cell lymphoma, T/null cell, primary cutaneous type
 2.2.8 Anaplastic large cell lymphoma (ALCL)Anaplastic large cell lymphoma, T/null cell, primary systemic type
Peripheral T-cell lymphoma not otherwise specified
3. Miscellaneous tumors Cutaneous mastocytosis
 3.1 Mast cell tumorsClassical Hodgkin lymphoma
 3.2 Hodgkin-like lymphoma
 3.3 Thymoma
 3.4 Thymic carcinoma
 3.5 Myelolipoma
 3.6 Malignant fibrous histiocytoma
4. Benign Lymphoid Proliferations
 4.1 Follicular lymphoid hyperplasia
 4.2 Atypical follicular lymphoid hyperplasia
 4.3 Paracortical lymphoid hyperplasia
Tumors of Myeloid System
1. Malignant Myeloid Proliferations Acute myeloid leukemias (AML)
 1.1 Precursor myeloid leukemia
  1.1.1 Acute myeloid leukemia/undifferentiated leukemia (AML M0) AML minimally differentiated
  1.1.2 Acute myeloid leukemia without maturation (AML M1)AML without maturation
  1.1.3 Acute myeloid leukemia with maturation (AML M2)AML with maturation
  1.1.4 Acute promyelocytic leukemia (AML M3)Acute myelomonocytic leukaemia
  1.1.5 Acute myelomonocytic leukemia (AML M4)
  1.1.6 Acute monoblastic leukemia (AML M5A)Acute monocytic leukaemia
  1.1.7 Acute monocytic leukemia (AML M5B)Acute erythroid leukaemia
  1.1.8 Erythroleukemia (AML M6A)
  1.1.9 Erythremic myelosis (AML M6B)
  1.1.10 Acute megakaryoblastic leukemia (AML M7)
 1.2 Chronic myelogenous leukemias (CML)Chronic neutrophilic leukaemia
  1.2.1 CML, neutrophilicChronic eosinophilic leukaemia
  1.2.2 CML, eosinophilic
  1.2.3 CML, monocyticPolycythemia vera
  1.2.4 Polycythemia veraEssential thrombocythemia
  1.2.5 Megakaryocytic myelosis/essential thrombocythemiaMyelodysplastic/myeloproliferative diseases
 1.3 Myelodysplastic syndromes
  1.3.1 Idiopathic myelofibrosis/myeloid metaplasia (MMM)Acute panmyelosis with myelofibrosis
  1.3.2 Chronic myelomonocytic leukemia (CMML)Chronic myelomonocytic leukaemia
  1.3.3 Refractory anemia with excess blasts (RAEB)Refractory anemia (myelodysplastic syndrome) with excess blasts (RAEB)
2. Solid Myeloid Proliferations Langerhans cell histiocytosis
 2.1 Cutaneous histiocytoma
 2.2 Cutaneous histiocytosis
 2.3 Systemic histiocytosisMacrophage/histiocytic neoplasm, histiocytic sarcoma
 2.4 Malignant histiocytosis/histiocytic sarcoma
 2.5 Granulocytic sarcoma
3. Benign Myeloid Proliferations
 3.1 Leukemoid reaction
 3.2 Leukopenia with left shift
 3.3 Post-toxic response
 3.4 Loeffler-like syndrome

From: Chapter 17, TUMORS OF HEMATOPOIETIC AND LYMPHOID TISSUES

Cover of Comparative Oncology
Comparative Oncology.
Baba AI, Câtoi C.
Copyright © 2007, The Publishing House of the Romanian Academy.

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