Algorithm for Lymphoma Classification Lymphoproliferation in Lymph Node Tumor Architecture (VALLI et al. 2002)

FollicularDiffuse
Grade according to the number of large cells per high power field (40 x) I 0–5 (FSCCL); II 6–15 (FMCL); III 16+(FLCL)
Floral variant*
Large irregular follicles with their mantle cell bands invading follicles
Large cell transformation
Fading germinal centers with diffuse proliferation of large cells
Mantle cell lymphoma - small nuclei, no nucleoli, scant cytoplasm, mantle cell architecture, occurring in lymph nodes, mucosal areas, marrow and spleen
Mantle cell lymphoma blastoid variant*
- vesicular nuclei with nucle-oli, scant cytoplasm and mantle cell architecture, occurring in above sites
Marginal cell lymphoma – medium-sized nuclei, ± nucleoli, abundant cytoplasm, and marginal zone architecture, occurring in lymph nodes (synonymous with monocytoid B-cell lymphoma)
In extranodal sites of mucosal origin = MALT
In spleen ± villous lymphocytes
Nuclear size

Small (nuclear diameter = 1.5–2 rbc)
Mitotic rate

Mixed, large and small

Large (nuclear diameter = 2–3 rbc)
High Leukemic
ALL (B)
ALL (T)

Nonleukemic
Precursor
B (B-LB)
Precursor
T (T-LB)
High grade B or Burkitt-like (SNCCL)
Law Leukemic
CLL (B)
Hairy cell (B)*
CLL (T)
Nonleukemic
SLL (B) (DSLL)
Plasmacytoid (DSLPL)
Plasmacytoma
SLL (T) (DSLL)
SLL (T) (DSLL)
T-cell rich large B-cell lymphoma (DMCL)
  • Large B Cell Neoplasms
    B-Cell Large cell lymphoma (DLCL)
    Diffuse large-cleaved cell (DLCL) Multilobated-BL
    Immunoblastic (IBL)
    Mediastinal-B-cell Lymphomas
    Myeloma
  • Large T Cell Neoplasm
  • Leukemic
    Large granular lymphocytic
    Leukemia (LGL): T-LGL; NK-LGL
  • Nonleukemic
    Extranodal
    Peripheral T-cell lymphoma
    Nodal
    Angioimmunoblastic T-lymphoma
    Nodal or extranodal
    Anaplastic large CD30+ Cell
    Angiocentric
    Cutaneous lymphomas:
    Mycosis fungoides
    Sezary syndrome
*

Rarely recognized in animals; ALL= Acute Lymphocytic Leukemia; CLL= Chronic Lymphocytic Leukemia; DLCL = Diffuse Large Cell Lymphoma; DLCCL = Diffuse Large-Cleaved Cell Lymphoma; DMCL= Diffuse Mixed Cell Lymphoma; DSLL= Diffuse Small Lymphocytic Lymphoma; DSLPL= DSL Plasmacytoid Lymphoma; FMCL = Follicular Mixed Cell Lymphoma; FLCL = Follicular Large Cell Lymphoma; FSCCL = Follicular Small Cleaved Cell Lymphoma; IBL = Immunoblastic Lymphoma; LBL= Lymphoblastic Lymphoma; LGL = Large Granular Lymphocytic Leukemia; MALT = Mucosa-Associated Lymphoid Tumor; PLL = Prolymphocytic Leukemia; SLL = Small Lymphocytic Lymphoma; SNCCL = Small Noncleaved Cell Lymphoma.

From: Chapter 17, TUMORS OF HEMATOPOIETIC AND LYMPHOID TISSUES

Cover of Comparative Oncology
Comparative Oncology.
Baba AI, Câtoi C.
Copyright © 2007, The Publishing House of the Romanian Academy.

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