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Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011.

Cover of TRP Channels

TRP Channels.

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Series Preface

The concept of signal transduction at the cellular level is now established as a cornerstone of biological sciences. Cells sense and react to environmental cues by means of a vast panoply of signaling pathways and cascades. While the steady accretion of knowledge regarding signal transduction mechanisms is continuing to add layers of complexity, this greater depth of understanding has also provided remarkable insights into how healthy cells respond to extracellular and intracellular stimuli and how these responses can malfunction in many disease states.

Central to advances in unraveling signal transduction is the development of new methods and refinement of existing ones. Progress in the field relies on an integrated approach that utilizes techniques drawn from cell and molecular biology, biochemistry, biophysics, physiology, genetics, immunology, and computational biology. The overall aim of this series is to collate and continually update the wealth of methodology now available for research into many aspects of signal transduction. Each volume is assembled by one or more editors who are leaders in their specialty. Their guiding principle is to recruit knowledgeable authors who will present procedures and protocols in a critical, yet reader-friendly, format. Our goal is to assure that each volume will be of maximum practical value to a broad audience, including students, seasoned investigators, and researchers who are new to the field.

Knowledge of the vast family of transient receptor potential (TRP) channels, which is the subject of this volume, has undergone a dramatic expansion in recent decades. A quick look at PubMed shows that over 6000 articles on this subject have appeared over the past 30 years, a figure that undoubtedly considerably underestimates the broad range of phenomena in which these channels are involved, especially since other designations were sometimes used in the earlier papers. The contents of the volume present both fundamental concepts regarding the properties of TRP channels and a variety of methodologies that can be employed to study them. Techniques that include the use of proteomics, antibodies, electrophysiology, fluorescence microscopy, and genetic manipulations are applied to cell and tissue preparations, as well as mouse models and lower eukaryotes.

In the Preface, the editor provides a brief history of the discovery of TRP channels, the recognition that they have a distinct role in regulating cellular Ca2+ movements, and the subsequent appreciation of their diversity. It can be anticipated that information concerning these channels will continue to steadily accumulate. It is hoped that the collection of methods presented in this book will constitute a valuable reference that will aid in the advancement of the field.

Joseph Eichberg

Series Editor

Copyright © 2011 by Taylor and Francis Group, LLC.
Bookshelf ID: NBK92820

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