Table 28Risk of vertebral fracture for calcium plus vitamin D, relative to placebo

Author, YearStudy DurationType of FractureNumber of Fractures, Calcium Plus Vit DNumber of fractures, Placebo or ControlOdds Ratio (95% CI)
All Fractures
Original Report
Grant, 200515362 monthsNew104/1,306196/1,3320.95 (0.76, 1.18)
Jackson, 200615184 monthsTotal2,101/18,1762,158/18,1060.97 (0.91, 1.03)
Porthouse, 200515224 monthsAll24/60722/6021.09 (0.6, 1.96)
Update Report
Larsen, 200515042 monthsAll fractures – men60/1,97426/8430.99 (0.62, 1.57)
Larsen, 200515042 monthsAll fractures – women285/2,983141/1,2730.75 (0.6, 0.94)
Salovaara, 201015436 monthsAny78/1,58694/1,6090.83 (0.61, 1.13)
Vertebral Fractures
Original 2007 Report
Grant, 200515362 monthsClinical vertebral0/1,3061/1,3320.14 (0, 6.96)
Jackson, 200615184 monthsClinical vertebral181/18,176197/18,1060.91 (0.75, 1.12)
Update Report
Salovaara, 201015436 monthsVertebral9/158613/16090.70 (030, 1.63)
Hip Fractures
Original 2007 Report
Grant, 200515362 monthsProximal femur46/1,30641/1,3321.15 (0.75, 1.76)
Jackson, 200615184 monthsHip175/18,176199/18,1060.87 (0.71, 1.07)
Porthouse, 200515224 monthsHip5/6072/6022.35 (0.53, 10.36)
Update Report
Salovaara, 201015436 monthsHip4/1,5862/1,6091.98 (0.4, 9.81)
Wrist Fractures
Original 2007 Report
Grant, 200515362 monthsDistal forearm33/1,30628/1,3321.21 (0.73, 2.01)
Jackson, 200615184 monthsLower arm or wrist565/18,176557/18,1061.01 (0.9, 1.14)
Update Report
Salovaara, 201015436 monthsDistal forearm23/1,58632/1,6090.73 (0.43, 1.24)

From: Results

Cover of Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: Update of a 2007 Report
Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: Update of a 2007 Report [Internet].
Comparative Effectiveness Reviews, No. 53.
Crandall CJ, Newberry SJ, Diamant A, et al.

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