BOX S-1Scientific Unknowns About SARS

  • What is the natural animal host of SCoV?
  • How was the virus transmitted to humans, and under what circumstances might transmission across species recur?
  • What is the potential for back-and-forth transmissions between humans and animals?
  • Is there a persistent animal reservoir?
  • Is the virus still present in human populations?
  • Will the transmission of SCoV prove to be seasonal, as for influenza?
  • What is the potential geographic range of SCoV?
  • What role do cofactors play in mediating the severity of SARS symptoms?
  • What explains the low rate of illness among children?
  • What causes superspreading events?
  • How important are routes of transmission other than infectious respiratory droplets? Under what circumstances do alternative modes of transmission occur?
  • How does pathogenesis unfold at the cellular level, and especially in nonrespiratory tissues?

SOURCES: Breiman presentation; Denison presentation (see Chapters 1 and 3 respectively); WHO, 2003j.

From: CORONAVIRUS RESEARCH AND SARS

Cover of Learning from SARS
Learning from SARS: Preparing for the Next Disease Outbreak: Workshop Summary.
Institute of Medicine (US) Forum on Microbial Threats; Knobler S, Mahmoud A, Lemon S, et al., editors.
Washington (DC): National Academies Press (US); 2004.
Copyright © 2004, National Academy of Sciences.

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