Table 2:

Target Identification and Target Validation

Year 1Year 2
Task NameCostQ1Q2Q3Q4Q1Q2Q3Q4
#1 Target Identification $200,000 $200,000
Previously published data on disease target $1,000
New biology that modulates a disease $199,000
#2 Target Validation $268,500 $468,500
Known molecules modulate target $100,000
Type of target has a history of success $1,000
Genetic confirmation $80,000
Availability of known animal models $7,500
Low throughput target validation assay that represents biology $70,000
Intellectual property of the target $7,500
Marketability of the target $2,500
#3 Identification of Actives $472,500 $941,000

From: Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start-up Companies

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Markossian S, Grossman A, Arkin M, et al., editors.
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