This future research needs (FRN) report is based on an Agency for Healthcare Research and Quality (AHRQ) comparative effectiveness review (CER) titled “First- and Second-Generation Antipsychotics for Children and Young Adults.” The purpose of the CER was to review and synthesize the evidence regarding the benefits and harms of first- and second-generation antipsychotics (FGAs and SGAs) for the treatment of various psychiatric and behavioral conditions in individuals 24 years of age or younger.

Contents

• Preface
• Acknowledgments
• Contributors
• Executive Summary
• Background
  • Objective
  • Context
  • Scope of Comparative Effectiveness Review
  • Findings of the CER
• Methods
  • Evidence Gaps
  • Identification of Stakeholders
  • Identification of Evidence Gaps
  • Criteria for Prioritization
  • Engagement of Stakeholders, Researchers, and Funders
  • Research Question Development and Research Design Considerations
• Results
  • Evidence Gaps After Stakeholder Input
  • Prioritization Results
  • Highest Priority Research Needs: PICOTS Information and Considerations of Potential Research Designs
  • Sample Size Requirements
• Discussion
  • Limitations and Challenges
• Conclusions
• References
• Abbreviations
• Appendixes
  • Appendix A Tables of FDA-Approved Indications for First- and Second-Generation Antipsychotics
  • Appendix B Evidence Gaps Identified in the Draft Comparative Effectiveness Review
  • Appendix C Flowchart of Future Research Needs (FRN) Process
  • Appendix D Effective Health Care Program Selection Criteria
  • Appendix E Searches for Ongoing Research May 23, 2011/June 6, 2011; and List of Relevant Ongoing Studies
  • Appendix F Online Prioritization Exercises
  • Appendix G Additional Relevant Characteristics and Study Design Considerations

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. 290 2007 10056 I, Prepared by: RTI-UNC Evidence-based Practice Center, Research Triangle Park, NC

Suggested citation:

Christian R, Saavedra L, Gaynes BN, Sheitman B, Wines RCM, Jonas DE, Viswanathan M, Ellis AR, Woodell C, Carey TS. Future Research Needs for First- and Second-Generation Antipsychotics for Children and Young Adults. Future Research Needs Paper No. 13. (Prepared by the RTI-UNC Evidence-based Practice Center under Contract No. 290 2007 10056 I.) Rockville, MD: Agency for Healthcare Research and Quality; February 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm

This report is based on research conducted by the RTI-UNC Evidence-based Practice Center (EPC) under contract to the Agency for healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290 2007 10056 I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help health care researchers and funders of research make well-informed decisions in designing and funding research and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of scientific judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical research and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances.

None of the investigators has any affiliations or financial involvement that conflicts with the material presented in this report.

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