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Christian R, Saavedra L, Gaynes BN, et al. Future Research Needs for First- and Second-Generation Antipsychotics for Children and Young Adults [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Feb. (Future Research Needs Papers, No. 13.)

Cover of Future Research Needs for First- and Second-Generation Antipsychotics for Children and Young Adults

Future Research Needs for First- and Second-Generation Antipsychotics for Children and Young Adults [Internet].

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Appendix ATables of FDA-Approved Indications for First- and Second-Generation Antipsychotics

Table A-1Food and Drug Administration-approved first-generation antipsychotics

Generic NameIndicationsAge Group for Which Approved
ChlorpromazineSchizophreniaAdults and children (1–12 years)
Bipolar disorder (mania)
Hyperactivity
Severe behavioral problems
DroperidolAgitationAdults and children
FluphenazinePsychotic disordersAdults
HaloperidolSchizophreniaAdults
Tourette syndrome
Hyperactivity
Severe childhood behavioral problems
LoxapineSchizophreniaAdults and children ≥12 years
PerphenazineSchizophreniaAdults and children ≥12 years
PimozideTourette syndromeAdults and children ≥12 years
ProchlorperazineSchizophreniaAdults and children >2 years and >20 pounds
Generalized nonpsychotic anxietyAdults
ThiothixeneSchizophreniaAdults and children ≥12 years
ThioridazineSchizophreniaAdults and children
TrifluoperazineSchizophreniaAdults and children ≥6 years
Generalized nonpsychotic anxietyAdults

Abbreviations: NA=not applicable

Table A-2Food and Drug Administration-approved second-generation antipsychotics

Generic NameIndicationsAge Group for Which Approved
Aripiprazole SchizophreniaAdults and adolescents (13–17 years)
Bipolar disorder (manic/mixed) monotherapy or adjunctive to lithium or valproateAdults and children (10–17 years)
Adjunctive treatment of major depressive disorderAdults
Irritability Associated with autistic disorderChildren (6–17 years)
Acute treatment of agitationAdults
Asenapine Acute schizophreniaAdults
Bipolar disorder type 1 (manic/mixed)
Clozapine Treatment resistant schizophreniaAdults
Reduce the risk of suicidal behavior in younger patients with schizophrenia.
Iloperidone Acute schizophrenia Adults
Olanzapine Schizophrenia
Bipolar disorder (manic/mixed)
Adults and adolescents (13–17 years)
Bipolar disorderAdults
Treatment resistant depression
Agitation associated with schizophrenia and bipolar I mania
Paliperidone Schizophrenia
Schizoaffective disorder
Adults
Quetiapine SchizophreniaAdults and adolescents (13–17 years)
Bipolar disorder (acute manic)Adults, children, and adolescents (10–17 years)
Bipolar disorder (depression)Adults
Bipolar disorder (maintenance)
Adjunctive therapy for major depressive disorder
Risperidone SchizophreniaAdults and adolescents (13–17 years)
Bipolar disorder (manic/mixed)Adults and adolescents (10–17 years)
Irritability associated with autismChildren (5–16 years)
Ziprasidone SchizophreniaAdults
Bipolar disorder (manic/mixed)
Bipolar disorder (maintenance)
Acute agitation in patients with schizophrenia

Abbreviations: NA, not applicable

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