Table 21Strength of evidence for schizophrenia and related psychosis (Key Question 3)

ComparisonOutcome (N Studies; N Patients)Strength of Evidence DomainsStrength of Evidence
ROBConsistencyDirectPrecision
FGAs vs. SGAsHRQL (1; 24)ModerateUnknownDirectImpreciseInsufficient
Medication adherence (3; 124)ModerateConsistentDirectImpreciseLow
Olanzapine vs. quetiapineMedication adherence (2; 80)ModerateConsistentDirectImpreciseLow
Olanzapine vs. risperidoneMedication adherence (5; 237)ModerateConsistentDirectImpreciseLow
Suicide (1; 78)ModerateUnknownDirectImpreciseInsufficient
Low- vs. high-dose aripiprazoleHRQL (1; 302)ModerateUnknownDirectImpreciseInsufficient
Suicide (1; 302)ModerateUnknownDirectImpreciseInsufficient
Low- vs. high-dose paliperidoneSuicide (1; 201)ModerateUnknownIndirectImpreciseInsufficient
Low- vs. high-dose quetiapineLegal system interactions (1; 141)ModerateUnknownDirectImpreciseInsufficient
Medication adherence (1; 141)ModerateUnknownDirectImpreciseInsufficient
Patient-, parent-, or care provider–reported outcomes (1; 222)ModerateUnknownDirectImpreciseInsufficient
Suicide (1; 141)ModerateUnknownDirectImpreciseInsufficient
Low- vs. high-dose risperidoneMedication adherence (1; 257)ModerateUnknownDirectImpreciseInsufficient
Suicide (2; 361)ModerateConsistentDirectNot pooledInsufficient
Low- vs. high-dose ziprasidoneSuicide (1; 17)ModerateUnknownIndirectImpreciseInsufficient
SGA vs. placeboHRQL (1; 302)ModerateUnknownDirectImpreciseInsufficient
Medication adherence (2; 167)ModerateConsistentDirectImpreciseLow
Patient-, parent-, or care provider–reported outcomes: Caregiver strain (1; 222)ModerateUnknownDirectPreciseInsufficient
Suicide (5; 990)ModerateConsistentDirectNot pooledLow

FGA = first-generation antipsychotic; HRQL = health-related quality of life; N = number; ROB = risk of bias; SGA = second-generation antipsychotic

From: Results

Cover of First- and Second-Generation Antipsychotics for Children and Young Adults
First- and Second-Generation Antipsychotics for Children and Young Adults [Internet].
Comparative Effectiveness Reviews, No. 39.
Seida JC, Schouten JR, Mousavi SS, et al.

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