Figure 30 is a metagraph depicting the effect of haloperidol versus SGAs on BPRS in schizophrenia and related psychosis. One study compared haloperidol and clozapine; another compared haloperidol with olanzapine and risperidone. A total of 71 patients were included in these studies. A meta-analysis of two studies found a significant difference favoring SGAs over haloperidol on the BPRS (MD = -11.44; 95 percent CI, -19.35 to -3.52). There was no evidence of heterogeneity between the studies (p = 0.99, I2 = 0 percent).

Figure 30FGAs versus SGAs on BPRS in schizophrenia and related psychosis

BPRS = Brief Psychiatric Rating Scale; CI = confidence interval; df = degrees of freedom; FGA = first-generation antipsychotics; IV = inverse variance; SD = standard deviation; SGA = second-generation antipsychotic

From: Results

Cover of First- and Second-Generation Antipsychotics for Children and Young Adults
First- and Second-Generation Antipsychotics for Children and Young Adults [Internet].
Comparative Effectiveness Reviews, No. 39.
Seida JC, Schouten JR, Mousavi SS, et al.

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