Question: Should CLO vs PLB be used in children with ADHD?

Quality assessmentSummary of findingsImportance
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsCLOPLBRelative (95% CI)Absolute
ADHD core symtpoms (teacher-rated) (follow-up 42 days; range of scores: 0-0; Better indicated by less)
1randomised trialno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone3829-SMD −0.57 (−1.06 to −0.08)⊕⊕⊕⊕
HIGH
CRITICAL
ADHD core symptoms (parent-rated) (follow-up 42 days; range of scores: 0-0; Better indicated by less)
1randomised trialno serious limitationsno serious inconsistencyno serious indirectnessserious1none3829-SMD −0.16 (−0.64 to 0.32)⊕⊕⊕○
MODERATE
CRITICAL
Conduct problems (teacher-rated) (follow-up 42 days; range of scores: 0-0; Better indicated by less)
1randomised trialno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone3829-SMD −0.68 (−1.18 to −0.18)⊕⊕⊕⊕
HIGH
CRITICAL
Conduct problems (parent-rated) (follow-up 42 days; range of scores: 0-0; Better indicated by less)
1randomised trialno serious limitationsno serious inconsistencyno serious indirectnessserious2none3829-SMD −0.31 (−0.8 to 0.17)⊕⊕⊕○
MODERATE
CRITICAL
Leaving study early for any reason (follow-up 42 days)
1randomised trialno serious limitationsno serious inconsistencyno serious indirectnessserious2none3/384/29RR 0.57 (0.14 to 2.36)59 fewer per 1,000⊕⊕⊕○
MODERATE
CRITICAL
1

No explanation was provided

2

Only one study and wide CI

From: APPENDIX 19, GRADE EVIDENCE PROFILES

Cover of Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder: Diagnosis and Management of ADHD in Children, Young People and Adults.
NICE Clinical Guidelines, No. 72.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society (UK); 2009.
Copyright © 2009, The British Psychological Society & The Royal College of Psychiatrists.

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