Table 36, Results of subgroup analysis from randomized controlled trials evaluating the effect of smoking on clinical outcome - Adjunctive Devices for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

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Table 36Results of subgroup analysis from randomized controlled trials evaluating the effect of smoking on clinical outcome

Study, Year (Total N)	Device Type	Device	Outcome	Characteristic	Effect Size (“X”R 95%CI)^*	P-Values for Interaction Between Subgroups^*
Cura, 2007⁹⁵ (N=140)	Distal Filter Embolic Protection	SpideRX™	STSR ≥ 70% 60 min postPCI	Current smoking	RR 1.12 (0.93 to 1.34)	NA

Stone, 2005¹¹² (N=501)	Distal Balloon Embolic Protection	GuardWire^® Plus	STSR ≥ 70% 30 min postPCI	Current smoking	RR 0.99 (0.81 to 1.22)	0.68
Stone, 2005¹¹² (N=501)	Distal Balloon Embolic Protection	GuardWire^® Plus	STSR ≥ 70% 30 min postPCI	No current smoking	RR 1.05 (0.87 to 1.27)

Haeck, 2009¹⁸ (N=284)	Proximal Balloon Embolic Protection	Proxis™	PostPCI STSR ≥ 70%	Current smoking	RR 1.41 (1.11 to 1.80)	0.78
Haeck, 2009¹⁸ (N=284)	Proximal Balloon Embolic Protection	Proxis™	PostPCI STSR ≥ 70%	No current smoking	RR 1.32 (0.90 to 1.95)

*: Some values were calculated based upon available trial data or estimated from figures
: Abbreviations: CI=confidence interval; min=minutes; N=total number of participants enrolled; NA=not applicable; PCI=percutaneous coronary intervention; RR=relative risk; STSR=ST-segment resolution

Adjunctive Devices for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention [Internet].

Comparative Effectiveness Reviews, No. 42.

Sobieraj DM, White CM, Kluger J, et al.

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