Figure 24-5. Comparison of activities of cholera enterotoxin (CT) with pertussis toxin (PT).

Figure 24-5Comparison of activities of cholera enterotoxin (CT) with pertussis toxin (PT)

The α-subunits of Gs and Gi, with GTP-binding sites, are ADP-ribosylated, respectively, by A1 peptide of CT or by the A subunit of PT, preventing, respectively, the hydrolysis of Gs-GTP to GDP or the responsiveness of Gi to inhibitory hormones, both effectively producing increases in adenylate cyclase activity. (Modified from Gill DM, Woolkalis M: Toxins which activate adenylate cyclase. CIBA Found Symp 112:57, 1985, with permission.)

From: Chapter 24, Cholera, Vibrio cholerae O1 and O139, and Other Pathogenic Vibrios

Cover of Medical Microbiology
Medical Microbiology. 4th edition.
Baron S, editor.
Copyright © 1996, The University of Texas Medical Branch at Galveston.

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