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Institute of Medicine (US); National Research Council (US); Pignone M, Russell L, Wagner J, editors. Economic Models of Colorectal Cancer Screening in Average-Risk Adults: Workshop Summary. Washington (DC): National Academies Press (US); 2005.

Cover of Economic Models of Colorectal Cancer Screening in Average-Risk Adults

Economic Models of Colorectal Cancer Screening in Average-Risk Adults: Workshop Summary.

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Appendix FMISCAN-colon: An Overview

, , , , , , and .

Slide 1. Appendix F MISCAN-colon: an Overview.

Slide 1

Appendix F MISCAN-colon: an Overview. SLIDE 1 NOTES: No notes.

Slide 2. Model Structure.

Slide 2

Model Structure. SLIDE 2 NOTES: Elements of the Miscan Model's structure are shown in this frame. The micro-simulation model treats time as a continuous variable, with discrete events occurring along the time line. So, for example, the appearance of a (more...)

Slide 3. Modeling Natural History.

Slide 3

Modeling Natural History. SLIDE 3 NOTES: The model is also a multi-disease model. By that I mean two things. First, although the model is intended to simulate a general population, it recognizes the inherent variation among individuals in the risk of (more...)

Slide 4. Natural History: Adenoma Carcinoma Sequence.

Slide 4

Natural History: Adenoma Carcinoma Sequence. SLIDE NOTES 4: This chart shows the disease states and transitions that are included in the model. For example, a person with no adenomatous lesions may develop a small adenoma, which may or may not progress (more...)

Slide 5. Natural History: Quantification of the Parameters.

Slide 5

Natural History: Quantification of the Parameters. SLIDE 5 NOTES: The parameters used to generate each hypothetical person's history were derived from a variety of sources, including data produced in clinical and epidemiological studies and, when no reliable (more...)

Slide 6. Natural History: Quantification of the Parameters (2).

Slide 6

Natural History: Quantification of the Parameters (2). SLIDE 6 NOTES: This chart provides an overview of which parameters were based on direct estimates and which resulted from a statistical fit procedure. Those based on assumptions are the ones that (more...)

Slide 7. Compliance.

Slide 7

Compliance. SLIDE 7 NOTES: To arrive at realistic assumptions about the degree of compliance that can be expected from a particular screening strategy, we relied on data reported from clinical trials and population surveys. Population surveys are problematic (more...)

Slide 8. Cost Assumptions.

Slide 8

Cost Assumptions. SLIDE 8 NOTES: Our assumptions about the costs of screening, follow-up and surveillance procedures are shown elsewhere in the workshop summary. The costs of CRC treatment vary with the number of months since the detection of a CRC. Initial (more...)

Slide 9. Model Validation.

Slide 9

Model Validation. SLIDE 9 NOTES: We have attempted to validate the model's predictions by comparing them with the results of several screening and surveillance trials. In comparison to the National Polyp Study (a trial of post-polypectomy surveillance) (more...)

Slide 10. Strengths and Weaknesses.

Slide 10

Strengths and Weaknesses. SLIDE 10 NOTES: No notes.

Slide 11. Work in process.

Slide 11

Work in process. SLIDE 11 NOTES: No notes.

REFERENCES

  • Levin TR, Palitz AM. Flexible sigmoidoscopy: An important screening option for average-risk individuals. Gastrointest Endosc Clin N Am. 2002;12(1):23–40. [PubMed: 11916159]
  • Loeve F, Boer R, Zauber AG, Van Ballegooijen M, Van Oortmarssen GJ, Winawer SJ, Habbema JDF. National Polyp Study data: Evidence for regression of adenomas. Int J Cancer. 2004;111(4):633–639. [PubMed: 15239144]
  • van Ballegooijen M, et al. Validation Study of the Miscan-Colon Program Sith Data From the CoCaP Sigmoidoscopy Program. Final Report to NCI. Rotterdam, NE: Erasmus Medical Center; 2002.
Copyright © 2005, National Academy of Sciences.
Bookshelf ID: NBK83877

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