Table 76Evidence summary table for trials of herbal interventions versus placebo

Chamomile versus placeboGinkgo biloba versus placeboCombined plant extracts versus placeboValerian extract versus placebo
No. trials
(total participants)
1 RCT
(57)
1 RCT
(107)
1 RCT
(264)
1 RCT
(24)
Study IDAMSTERDAM2009WOELK2007HANUS2004ANDREATINI2002
Benefits (end of treatment)
HAM-ASMD −0.54 (−1.07, −0.01)
K = 1, N = 57
Quality: moderate
SMD −0.58 (−1.01, −0.15)
K = 1, N = 107
Quality: high
SMD −0.35 (−0.59, −0.11)
K = 1, N = 264
Quality: high
SMD 0.09 (−0.71, 0.89)
K = 1, N = 24
Quality: moderate
Non-response (50% reduction in HAM-A)RR 0.69 (0.41, 1.15)
K = 1, N = 57
Quality: moderate
RR 0.75 (0.58, 0.97)
K = 1, N = 107
Quality: moderate
RR 0.80 (0.66, 0.98)
K = 1, N = 264
Quality: moderate
Non-remission

RR 0.97 (0.87, 1.07)
K = 1, N = 107
Quality: moderate
Harms (end of treatment)
Discontinuation due to adverse eventsRR 1.04 (0.07, 15.77)
K = 1, N = 57
Quality: moderate
RR 1.03 (0.21, 5.01)
K = 1, N = 264
Quality: moderate
Discontinuation due to any reasonRR 3.75 (0.20, 70.65)
K = 1, N = 24
Quality: moderate
RR 1.00 (0.17, 5.98)
K = 1, N = 24
Quality: moderate

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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