Table 52Study information table for trials of SSRIs comparing different doses

Escitalopram 5 mg versus 10 mgEscitalopram 10 mg versus 20 mgParoxetine 20 mg versus 40 mg
No. trials (total participants)1 RCT
(N = 270)
1 RCT
(N = 269)
1 RCT
(N = 386)
Study IDBALDWIN2006BALDWIN2006RICKELS2003
N/% female270/64%269/64%386/55%
Mean age (years)414140
DiagnosisGAD by DSM-IV-TRGAD by DSM-IV-TRGAD by DSM-IV
Baseline severity (HAM-A): mean (SD)Escitalopram 5 mg 27.1 (4.5); 10 mg 26.0 (4.1)Escitalopram 10 mg 26.0 (4.1); 20 mg 27.7 (4.9)Paroxetine 20 mg 24.1 (3.6); 40 mg 23.8 (3.4)
Treatment length12 weeks12 weeks9 weeks
Follow-upEnd of treatmentEnd of treatmentEnd of treatment

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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