Table 45Evidence summary table for trials of antidepressants versus other antidepressants

Escitalopram versus paroxetineSertraline versus paroxetineEscitalopram versus venlafaxineDuloxetine versus venlafaxine
No. trials (total participants)2 RCTs (N = 523)1 RCT (N = 55)1 RCT (N = 404)2 RCTs (N = 653)
Study ID
BALL2005BOSE2008
Benefits (end of treatment)
HAM-ASMD −0.32 (−0.50, −0.14)
MD −1.66 (−2.59, −0.73)
K = 2, N = 523
Quality: high
SMD 0.03 (−0.13, 0.18)
MD 0.20 (−0.92, 1.32)
K = 2, N = 653
Quality: moderate
Non-responseRR 0.60 (0.45, 0.81)
K = 1, N = 409
Quality: high
RR 0.81 (0.39, 1.70)
K = 1, N = 53
Quality: moderate
RR 0.98 (0.77, 1.26)
K = 1, N = 264
Quality: moderate
RR 1.04 (0.78, 1.39)
K = 2, N = 653
Quality: low
Non-remissionRR 1.12 (0.70, 1.79)
K = 1, N = 53
Quality: moderate
RR 0.99 (0.85, 1.16)
K = 1, N = 264
Quality: moderate
RR 1.07 (0.94, 1.21)
K = 2, N = 653
Quality: moderate
Quality of lifeSMD 0.02 (−0.13, 0.18)
MD 0.18 (−0.83, 1.20)
K = 2, N = 653
Quality: moderate
Harms (end of treatment)
Discontinuation due to adverse eventsRR 0.88 (0.46, 1.69)
K = 1, N = 409
Quality: moderate
RR 0.54 (0.25, 1.16)
K = 1, N = 264
Quality: moderate
RR 1.18 (0.78, 1.77)
K = 2, N = 653
Quality: moderate
DiarrhoeaRR 1.13 (0.59, 2.17)
K = 1, N = 409
Quality: moderate
RR 1.86 (0.95, 3.62)
K = 1, N = 326
Quality: moderate
Sexual problemsRR 0.57 (0.25, 1.32)
K = 1, N = 409
Quality: moderate
AnxietyRR 0.52 (0.19, 1.45)
K = 1, N = 409
Quality: moderate

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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