Figure 2. HCV strategies for evasion and antagonism of the innate immune defense pathways.

Figure 2

HCV strategies for evasion and antagonism of the innate immune defense pathways. Recognition of HCV PAMPs by RIG-I or TLR PRRs can lead to strong activation of antiviral genes and effector molecules. HCV has evolved a number of strategies to promote persistence and viral growth, including direct targeting of IPS-1, antagonism of the JAK/STAT signaling program, as well as inhibiting direct antiviral molecules. See text for details. Figure modified from reference 29.

From: Innate Immune Evasion Strategies of HCV and HIV: Common Themes for Chronic Viral Infection

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