Table 5Example of GRADE evidence profile

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsInterventionControlRelative (95% CI)Absolute
Outcome 1
6Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious1None8/1917/150RR 0.94
(0.39 to 2.23)
0 fewer per 100
(from 3 fewer to 6 more)
⊕⊕⊕○
MODERATE
Outcome 2
6Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious2None55/23663/196RR 0.44
(0.21 to 0.94)3
18 fewer per 100
(from 2 fewer to 25 fewer)
⊕⊕⊕○
MODERATE
Outcome 3
3Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessNo serious imprecisionNone8381MD −1.51
(−3.81 to 0.8)
⊕⊕⊕⊕ HIGH
Outcome 4
3Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious4None8893SMD −0.26
(−0.56 to 0.03)
⊕⊕⊕○
MODERATE
Outcome
4Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious4None109114SMD −0.13
(−0.6 to 0.34)
⊕⊕⊕○
MODERATE
1

The upper confidence limit includes an effect that, if it were real, would represent a benefit that, given the downsides, would still be worth it.

2

The lower confidence limit crosses a threshold below which, given the downsides of the intervention, one would not recommend the intervention.

3

Random-effects model.

4

95% CI crosses the minimal importance difference threshold.

From: 3, METHODS USED TO DEVELOP THIS GUIDELINE

Cover of Depression in Adults with a Chronic Physical Health Problem
Depression in Adults with a Chronic Physical Health Problem: Treatment and Management.
NICE Clinical Guidelines, No. 91.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © 2010, The British Psychological Society & The Royal College of Psychiatrists.

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