Table 1. Immunohistochemical Markers

Tumor TypeBeta-HCGAFPPLAP c-kit
Choriocarcinoma + -±-
Embryonal carcinoma - -+-
Germinoma (syncytiotrophoblastic) +-±+
Immature teratoma ±±-±
Mature teratoma----
Mixed germ cell tumor ±±±±
Pure germinoma--±+
Yolk sac tumor- +±-

AFP = alpha-fetoprotein; HCG = human chorionic gonadotropin; PLAP = placental alkaline phosphatase; + = positive; - = negative; ± = equivocal.

From: Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.

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