Table B-1Literature abstract screening (PICO) criteria

Inclusion criteriaExclusion criteria
Population (P)
-

History of past or current skin cancer: melanoma, basal cell carcinoma, squamous cell carcinoma

-

Patients with new or recurrent pigmented or suspicious skin lesions, including facial skin cancers, basal cell nevus syndrome, and Gorlin's Syndrome

-

Included all age, race, sex, and countries

-

All other skin cancers

-

Kaposi's sarcoma

-

Merkel cell carcinoma

-

Mycosis fungoides

-

Skin lymphoma

-

Sézary syndrome

-

Choroidal melanoma

-

Subungal, ocular, and visceral lesions

-

Head and neck cancers

-

Metastases

Diagnostic device of interest (I)
-

General

-

Full body photography

-

Digital photography

-

Dermoscopy

-

Limited Use

-

Confocal microscopy

-

Ultrasound, including laser Doppler, color mapping

-

Photodynamic diagnosis

-

Investigational

-

Multiphoton laser scanning microscopy

-

Multispectral imaging with computer-analysis

-

Optical coherence tomography

-

Epidermal genetic tape stripping

-

Bio-electrical impedance

-

Thermography

-

Spectrophotometric intracutaneous Analysis (SIAscopy)

-

Spectrophotometry

-

Photoacoustic microscopy

-

Photodynamic therapy (PDT)

-

Colorimetry

-

18F-FDG positron emission tomography (PET)

-

Computer tomography (CT)

-

Single photon emission computed tomography (SPECT)

-

Lymphoscintigraphy

-

Fluorescent in situ hybridization

-

Therapeutic interventions

-

Pre-surgical planning

Comparator (C)
-

Biopsy

-

Any intervention and device listed above

-

Clinical exam/assessment

Outcomes (O)
-

Any clinical outcomes reported (including skin cancer survival and overall survival)

-

Quality of life measures

-

Intermediate outcomes, e.g., changes in size and number of lesions

-

Lesion characterizations

-

Adverse events, harms, or safety data

-

FDA clearance/approval status (if applicable)

-

Process measures, e.g., time to specialty referral, hospital wait times, healthcare utilization

-

Diagnostic test accuracy, e.g., sensitivity, specificity, positive predictive value, negative predictive value

-

Metastases detection

-

Prognosis prediction

Study design
-

Systematic reviews

-

Narrative reviews

-

Trials

-

Comparative cohorts

-

Case series

-

Case reports

-

Diagnostic tests

From: Appendix B, Inclusion and Exclusion Criteria

Cover of Noninvasive Diagnostic Techniques for the Detection of Skin Cancers
Noninvasive Diagnostic Techniques for the Detection of Skin Cancers [Internet].
Comparative Effectiveness Technical Briefs, No. 11.
Parsons SK, Chan JA, Yu WWet al., authors; Sen S, editor.

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