Figure 2.. Self-termination of mast cell activation by allergen.

Figure 2.

Self-termination of mast cell activation by allergen. Multivalent protein allergens like birch profilin recognized by allergen-specific IgE bound to high.affinity IgE receptor on the surface of mast cells stimulates degranulation and release of epitope-destroying proteases, such as chymases. This is a negative feedback loop that reduces allergic inflammation by destroying allergen.

From: MAST CELL PROTEASES AS PROTECTIVE AND INFLAMMATORY MEDIATORS

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.