Table 83GDG judgment on drugs safety and efficacy in endoscopy

DRUG (alone, or with local anaesthesia)RouteDoseAgeProcedureEfficacySafetyEvidence levelRef
IN M vs. PlaceboIN0.2 mg/kgage range: 2-12 yEndoscopyYes (Effective) NSD in distress scoreNot reportedRCT Mod-lowFishbein 199767
IV P vs. IV F/IV PIVFentanyl: 1mcg/kg
PRO: 3mg/kg
TA: Lidocaine larynx and EMLA cream
PRO/Fenta 6.8 y (SD2.8)
PRO/TA 6.7 y (2.9)
EndoscopyYes (Effective)Yes (Well tolerated)lowDisma 200556
P/LA/TAIVPRO: mixed according to age/weight
LA: 1 to 10 mg
TA: EMLA cream
<1 to <21y
Upper gastrointestinal endoscopy proceduresNot reportedYes (Well tolerated)Very lowBarbi 200625
P/LA/TAIVPRO: mixed according to age/weightoverall
<1 to <21y
Upper endoscopies, colonoscopies, painful proceduresNot reportedYes (Well tolerated)Very lowBarbi 200324
6.12.7LA: 1 to 10 mg
6.12.8TA: EMLA cream

From: 6, Drugs for sedation in infants, children and young people

Cover of Sedation in Children and Young People
Sedation in Children and Young People: Sedation for Diagnostic and Therapeutic Procedures in Children and Young People [Internet].
NICE Clinical Guidelines, No. 112.
National Clinical Guideline Centre (UK).
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