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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Danhof-Pont MB, van Veen T, Zitman FG. Biomarkers in burnout: a systematic review. Journal of Psychosomatic Research 2011; 70(6): 505-524. [PubMed: 21624574]
Abstract
BACKGROUND: Burnout is a stress state characterized by symptoms of mental exhaustion and physical fatigue, detachment from work, and feelings of diminished competence. Several biomarkers have been tested for association with burnout, but the results are conflicting.
AIM: The objective of this review was to identify potential biomarkers for burnout.
METHODS: We carried out a systematic review of studies comparing biomarkers in individuals with burnout and healthy controls, or individuals with low scores and those with high scores on burnout questionnaires. Literature searches in MEDLINE and EMBASE were performed. We describe biomarkers on which at least three studies were available. Where appropriate, a meta-analysis was carried out.
RESULTS: We identified 31 studies on 38 biomarkers involved in the hypothalamus-pituitary-adrenal axis, autonomic nervous system, immune system, metabolic processes, antioxidant defense, hormones, and sleep. At least 3 studies were available for cortisol in saliva and blood, blood pressure, heart rate, cholesterol, dehydroepiandrosterone sulfate, (numbers or activity of) natural killer cells, C-reactive protein, and prolactin. The comparability of studies was limited, due to differences in the methods used to characterize patients and controls, to assess biomarkers, and to control for confounders. Furthermore, burnout was operationalized in different ways. Meta-analyses showed no differences for cortisol awakening response and cortisol awakening response after administration of dexamethasone, cortisol in blood, and blood pressure.
CONCLUSIONS: No potential biomarkers for burnout were found, largely due to the incomparability of studies. We emphasize the need for a dimensional and longitudinal approach in future research to account for the heterogeneity of burnout.
Copyright © 2010 Elsevier Inc. All rights reserved.
- Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.[Psychoneuroendocrinology. 2006]Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.Mommersteeg PM, Heijnen CJ, Verbraak MJ, van Doornen LJ. Psychoneuroendocrinology. 2006 Feb; 31(2):216-25. Epub 2005 Sep 16.
- Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance.[Biol Psychol. 2008]Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance.Bellingrath S, Weigl T, Kudielka BM. Biol Psychol. 2008 Apr; 78(1):104-13. Epub 2008 Feb 2.
- Physiological differences between burnout patients and healthy controls: blood pressure, heart rate, and cortisol responses.[Occup Environ Med. 2003]Physiological differences between burnout patients and healthy controls: blood pressure, heart rate, and cortisol responses.De Vente W, Olff M, Van Amsterdam JG, Kamphuis JH, Emmelkamp PM. Occup Environ Med. 2003 Jun; 60 Suppl 1:i54-61.
- Review [Neuro-endocrine correlates of burnout].[Tijdschr Psychiatr. 2012]Review [Neuro-endocrine correlates of burnout].Verhaeghe J, Van Den Eede F, Van Den Ameele H, Sabbe BG. Tijdschr Psychiatr. 2012; 54(6):517-26.
- Review The medical perspective on burnout.[Int J Occup Med Environ Health...]Review The medical perspective on burnout.Kakiashvili T, Leszek J, Rutkowski K. Int J Occup Med Environ Health. 2013 Jun; 26(3):401-12. Epub 2013 Sep 10.
- Biomarkers in burnout: a systematic review - Database of Abstracts of Reviews of...Biomarkers in burnout: a systematic review - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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