Figure 4. Mechanoreceptor complex model.

Figure 4

Mechanoreceptor complex model. In this model integrins are attached to the extracellular ligand and the cytoskeleton complex. Integrin-mediated adhesion to extracellular proteins (i.e. collagen II, fibronectin, laminin, vitronectin) activates and recruits cytoskeletal associated proteins including paxillin, tensin, vincullin, talin, zyxin and α-actinin which, bind to actin filaments. This complex also has the ability to activate subcellular signalling proteins such as FAK (focal adhesion kinase).

From: Functional Roles of Mechanosensitive Ion Channels, ß1 Integrins and Kinase Cascades in Chondrocyte Mechanotransduction

Cover of Mechanosensitivity in Cells and Tissues
Mechanosensitivity in Cells and Tissues.
Kamkin A, Kiseleva I, editors.
Moscow: Academia; 2005.
Copyright © 2005, Academia Publishing House Ltd.

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