Table 2Effect of verapamil (0.2 mg/kg), gadolinium (20 mg/kg) and ryanodine (5 μg/kg) on probability, duration of atrial fibrillation and on the time before paroxysm initiation during ACh infusion into the sinus node artery or during vagal stimulation

ControlDrug
AChProbability %Duration secTime initiation secProbability %Duration secTime initiation sec
Verapamil96 ± 316 ± 28.6 ± 1.494 ± 4 37 ± 7* 16.5 ± 3.2*
Gadolinium96 ± 437 ± 512.9 ± 2.810033 ± 411.3 ± 1.7
Ryanodine96 ± 333 ± 38.1 ± 1.786 ± 7 24 ± 3* 14.7 ± 2.2*
ControlDrug
VSProbability %Duration secTime initiation secProbability %Duration secTime initiation sec
Verapamil78 ± 615 ± 24.8 ± 0.479 ± 11 25 ± 5* 4.1 ± 0.5
Gadolinium69 ± 1324 ± 65.6 ± 1.165 ± 1331 ± 85.9 ± 1.1
Ryanodine78 ± 532 ± 53.3 ± 0.3 4 ± 3*

AF = atrial fibrillation; VS = vagal stimulation. * = p<0.05 vs. control. (Modified from Fedorov VV et al. [2024], with permission).

From: The Role of Mechano-Electrical Feedback in the Cholinergic Atrial Fibrillation Initiation

Cover of Mechanosensitivity in Cells and Tissues
Mechanosensitivity in Cells and Tissues.
Kamkin A, Kiseleva I, editors.
Moscow: Academia; 2005.
Copyright © 2005, Academia Publishing House Ltd.

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