Figure 7. Mechanosensitivity of K+ currents.

Figure 7

Mechanosensitivity of K+ currents. A: Iv curves of net membrane currents measured with ramp commands repolarizing the cell from +60 to -100 mV at a rate of 100 mV/s. Blue trace before, red trace during 10 μm stretch. Arrows mark the shift of resting potential from -90 to -70 mV, the reduction of the hump of outward current at -60 mV and the increase in outward current at +50 mV. B: The N-shape of the control i-v curve is attributed to the inward rectifier IK1, the driving force (Vm –EK) is multiplied with a conductance GK1 that deactivates when the membrane is depolarized (blue curve). C: Modelling the control currents by superimposition of IK1 with an outwardly rectifying K+ current IKo. D: Modelling the currents during stretch. In addition to the activation of ISAC, deactivation of IK1 is necessary to model reduced the reduced slope and the reduced hump of outward current (-60mV) of the iv curve. In addition, the increase in outward current at positive potentials needs the postulate that stretch enhances IKo. (Unpublished). (See color insert # 10).

From: Isolated Cardiomyocytes: Mechanosensitivity of Action Potential, Membrane Current and Ion Concentration

Cover of Mechanosensitivity in Cells and Tissues
Mechanosensitivity in Cells and Tissues.
Kamkin A, Kiseleva I, editors.
Moscow: Academia; 2005.
Copyright © 2005, Academia Publishing House Ltd.

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