Figure 19. Induction of net inward currents by local stretch is graded and reversible.

Figure 19

Induction of net inward currents by local stretch is graded and reversible. On-line pen records of membrane current; K+ currents are not suppressed. Membrane potential clamped to a holding potential of -45 mV, 140 ms pulses to 0 mV at 1 Hz. Amplitude of stretch and amount of stretch-induced inward current at -45 mV are indicated. A to D: Amount of inward current increases with the extent of stretch. E: During 10 min of stretch, inward current remains constant meaning no inactivation occurs. After stretch, current relaxes back to the value before stretch. Note: Stretches by 2 μm and 4 μm did not change the current (not illustrated). (From Kamkin et al. [06], with permission from European Society of Cardiology).

From: Mechano-Electric Feedback in the Heart: Evidence from Intracellular Microelectrode Recordings on Multicellular Preparations and Single Cells from Healthy and Diseased Tissue

Cover of Mechanosensitivity in Cells and Tissues
Mechanosensitivity in Cells and Tissues.
Kamkin A, Kiseleva I, editors.
Moscow: Academia; 2005.
Copyright © 2005, Academia Publishing House Ltd.

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