Figure 1. A diagram of the two major intracellular trafficking pathways and the compartments they connect: The exocytic pathway carries proteins and lipids from the endoplasmic reticulum through the Golgi apparatus to the plasma membrane (PM).

Figure 1

A diagram of the two major intracellular trafficking pathways and the compartments they connect: The exocytic pathway carries proteins and lipids from the endoplasmic reticulum through the Golgi apparatus to the plasma membrane (PM). The endocytic pathway internalizes cargo from the cell milieu or the PM through a set of endosomes to the degradative cellular compartment, the lysosome. The two pathways are connected by bi-directional transport between the Golgi and endosomes. Various proteins follow their specific routes towards their destination; e.g., secreted cargo and PM receptors and transporters to the PM; newly synthesized endosomal and lysosomal proteins to endosomes and lysosomes; signaling molecules and PM receptors to early endosmes; and nutrients to lysosomes.

From: Overview of Intracellular Compartments and Trafficking Pathways

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