Figure 2. . Panel a: Schematic representation of the MEN1 gene.

Figure 2.

Panel a: Schematic representation of the MEN1 gene. White boxes are translated exons, hatched boxes are untranslated. The start (ATG) and stop (TGA) codons in exons 2 and 10, respectively, are indicated. NLS1, NLSa, and NLS2 are the nuclear localization signals located, respectively, at codons 479-497, 546-572, and 588-608. Panel b: Schematic representation of the menin protein and mapping of its interaction with protein partners. Black bars indicate the regions of menin implicated in the binding to each of its partners.

From: Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome

Cover of Cancer Syndromes
Cancer Syndromes [Internet].
Riegert-Johnson DL, Boardman LA, Hefferon T, et al., editors.
Copyright © 2009-, Douglas L Riegert-Johnson.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.