Table 5SAR of Probe CID 2440433 [ML184]

Image ml186fu27.jpg
Compound IDsAgonists EC50 (μM)Antagonists IC50 (μM)
PubChem CIDPubChem SIDSBCCG MLS-#GPR 55GPR 35CB1CB2GPR 35CB1CB2
#R1R2R3
14-NO2
Image ml186fu28.jpg
Image ml186fu29.jpg
483211987225728MLS-02594810.72/0.59
Avg 0.66
>32>32>323232>32
22,3-diMe
Image ml186fu30.jpg
Image ml186fu31.jpg
244043387225729MLS-02576090.25/0.27
Avg 0.26
>32>32>323228.5/15
Avg 21.75
11.1/19.1
Avg 15.1
33-Cl
Image ml186fu30.jpg
Image ml186fu31.jpg
2498208587544642MLS-04355430.58/0.64
Avg 0.61
>32>32>32>3226.9/27.4
Avg 27.1
>32
42,3-diMeCl
Image ml186fu31.jpg
1627300687544633MLS-04355341.69/1.37
Avg 1.53
>32>32>32>3210.5/20.8
Avg 15.6
>32
5H
Image ml186fu30.jpg
Image ml186fu31.jpg
246625987544624MLS-04355282.26/1.08
Avg 1.67
>32>32>32>32>32>32
62,3-diMeH
Image ml186fu31.jpg
209019487544618MLS-04355263.78/2.46
Avg 3.12
>32>32>32>32>32>32
74-NO2Cl
Image ml186fu31.jpg
350430687544621MLS-04355271.93/12
Avg 6.98
>32>32>32>32>32>32
82-Me, 5- Cl
Image ml186fu30.jpg
Image ml186fu31.jpg
1626262187544631MLS-043553211.6/6.04
Avg 8.84
>32>32>32>32>32>32
92,3-diMeH
Image ml186fu41.jpg
251872587544622MLS-0433928>32>32>32>32>32>32>32
10H
Image ml186fu42.jpg
Image ml186fu43.jpg
1623303587544629MLS-0435530>32>32>32>32>32>32>32
112-Me
Image ml186fu44.jpg
Image ml186fu45.jpg
1756396987544639MLS-0435540>32>32>32>32>32>32>32
122-OEt
Image ml186fu46.jpg
Image ml186fu31.jpg
2516160387544645MLS-0421957>32>32>32>32>32>32>32
13H
Image ml186fu48.jpg
Image ml186fu43.jpg
2570268587544632MLS-0435533>32>32>32>32>328.35/10.4
Avg 9.36
>32

From: Screening for Selective Ligands for GPR55 - Agonists

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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