Figure 2. Hsp70 protects neurons from a variety of central nervous system insults.

Figure 2

Hsp70 protects neurons from a variety of central nervous system insults. Several surviving, beta-galactosidase (β-gal) positive cells (arrows) which received a Hsp70 overexpressing vector are evident within an ischemic striatum 48 h after 1 hour of middle cerebral artery occlusion (stroke) (A) compared to one receiving control vector where virtually no surviving cells are seen (B). Following 8 minutes of forebrain ischemia, more transfected, β-gal-positive CA1 neurons are present within a hippocampus given Hsp70 vector (C) versus control vector (D). Insets show detail of transfected neurons within the hippocampal CA1 subsector. Brain sections are counterstained with cresyl violet. (C & D are reprinted with permission from: Yenari MA et al. In: J Krieglstein & S Klumpp (eds), Pharmacology of Cerebral Ischemia, 457–472 “ 2000 Medpharm Scientific Publishers; Yenari MA et al. In Slikker W & Trembly B (eds), Neuroprotective Agents: 5th International Conference, 939:340–357 ”2001 NY Acad Sci; Yenari MA et al. Neurol Res 23:543–552“ 2001 Forefront Publishing Group.)

From: Heat Shock Proteins and Neuroprotection

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