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Maglione M, Maher AR, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Sep. (Comparative Effectiveness Reviews, No. 43.)

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Off-Label Use of Atypical Antipsychotics: An Update [Internet].

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Appendix CPreviously Published Meta-Analyses

Depression

Aripiprazole Efficacy

RCTs (Author, year)Meta-analysis (Aripiprazole)
Arbaizar, 2009301Nelson, 2009152
Berman, 2007155XX
Marcus, 2008154XX
Berman, 2008: same study as156X

Olanzapine Efficacy

RCTs (Author, year)Meta-analysis (Olanzapine)
Nelson, 2009152Papakostas, 2007151
Shelton, 2001302XX
Shelton, 2005303XX
Corya, 2006304XX
Thase, 2007174X
Thase, 2006 same study as174X

Risperidone Efficacy

RCTs (Author, year)Meta-analysis (Risperidone)
Nelson, 2009152Papakostas, 2007151
Mahmoud, 2007166X
Reeves, 2008164X
Keitner, 2009165X
Keitner, 2006 not includedX
Gharabawi, 2006 same study as167X

Quetiapine Efficacy

RCTs (Author, year)Meta-analysis (Quetiapine)
Nelson, 2009152Papakostas, 2007151
Mattingly, 2006161XX
McIntyre, 200786X
El-Khalili, 2008305X
Khullar, 2006 not includedXX
Earley, 2007 same study as306X
McIntyre, 2006 same study as86X

PTSD

Risperidone Efficacy

RCTs (Author, year)Meta-analysis (Risperidone)
Pae, 2008228
Bartzokis, 2005230X
Reich, 2004231X
Monnelly, 2003232X
Padala, 2006233X
Hamner, 2003234X

Olanzapine Efficacy

RCTs (Author, year)Meta-analysis (Olanzapine)
Pae, 2008228
Stein, 2002235X
Butterfield, 2001236X

Risperidone AE

RCTs (Author, year)Meta-analysis (Risperidone)
Pae, 2008228
Bartzokis, 2005230X
Reich, 2004231X
Monnelly, 2003232X
Padala, 2006233X
Hamner, 2003234X

Olanzapine AE

RCTs (Author, year)Meta-analysis (Olanzapine)
Pae, 2008228
Stein, 2002235X
Butterfield, 2001236X

Personality Disorder

Olanzapine Efficacy

RCTs (Author, year)Meta-analysis (Olanzapine)
Ingenhoven, 2010213
Zanarini, 2001214X
Soler, 2005215X
Bogenschutz, 2004216X

Risperidone Efficacy

RCTs (Author, year)Meta-analysis (Risperidone)
Ingenhoven, 2010213
Koenigsberg, 2003217X

Aripiprazole Efficacy

RCTs (Author, year)Meta-analysis (Aripiprazole)
Ingenhoven, 2010213
Nickel, 2006218X

Substance Abuse

Risperidone Efficacy

RCTs (Author, year)Meta-analysis (Aripiprazole)
Amato, 2007275
Grabowski, 2004274X
Levin, 1999268X
Smelson, 2004270X

Olanzapine Efficacy

RCTs (Author, year)Meta-analysis (Aripiprazole)
Amato, 2007275
Kampman, 2003264X
Reid, 2005265X
Smelson, 2006245X

Anxiety

Quetiapine Efficacy

RCTs (Author, year)Meta-analysis (Quetiapine)
Depping, 201082
Bundelow, 200788X
Eriksson, 2008X
Joyce, 200894X
Merideth, 2008 87X

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