From: Laetrile/Amygdalin (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 2. In Vivo Studiesa
| Reference | Animal Model | Outcome |
|---|---|---|
| [2] | Four transplantable rodent tumors (L1210 lymphoid leukemia, P388 lymphocytic leukemia, B16 melanoma, and Walker 256 carcinosarcoma) | No antitumor activity of amygdalin alone (25–3,200 mg/kg); potentiation of toxicity of amygdalin when combined with beta glucosidase |
| [3] | Three transplantable rodent tumors (osteogenic sarcoma, Lewis lung carcinoma, and P388 leukemia) | No antitumor activity at 20% of lethal dose (LD20) |
| [4] | DMBA-induced rat mammary carcinoma and the following transplanted experimental tumors: sarcoma 180, plasma cell tumor LPC-1, leukemia L1210, Mecca lymphosarcoma, Ridgway osteogenic sarcoma, sarcoma T241, mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256 | Not effective at treating, preventing, or delaying development of tumors |
| [6] | B16 melanoma and BW5147 AKR leukemia | Ineffective |
| [9] | Murine mammary adenocarcinoma | No effect of amygdalin alone. Enhanced antitumor activity of combination of oral vitamin A, amygdalin given intramuscularly, and enzymes injected into and around the tumor |
| [10] | Human breast and colon xenografts | Inactive |
| [19] | HeLa human cervical cancer cell xenografts | Modest tumor growth inhibition in mice receiving 300 mg/kg intraperitoneally daily for 14 days |
DMBA = dimethylbenz-alpha-anthracene; kg = kilogram(s); mg = milligram(s).
aFor additional information and definition of terms, see text and the NCI Dictionary of Cancer Terms.