Table 5. Common Genetic Syndromes Associated With Adenomatous Polyposis

Syndrome GeneGene FunctionHereditary Pattern
Attenuated familial adenomatous polyposis APC (5’ mutations), AXIN2 Tumor suppressor Dominant
Familial adenomatous polyposis (Gardner syndrome) APCTumor suppressor Dominant
Lynch syndrome (hereditary nonpolyposis colorectal cancer) MSH2, MLH1, MSH6, PMS2, EPCAMRepair/stabilityDominant
Li-Fraumeni syndrome TP53 (p53)Tumor suppressor Dominant
MYH-associated polyposis MYH (MUTYH) Repair/stability Recessive
Turcot syndromeAPC Tumor suppressor Dominant
MLH1 Repair/stability Dominant

From: Unusual Cancers of Childhood Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.