Figure 9. Effect of calreticulin-to-calmodulin ratio on catalytic activity of eNOS.

Figure 9

Effect of calreticulin-to-calmodulin ratio on catalytic activity of eNOS. A: purified eNOS was incubated in the absence of calreticulin but in the presence of increasing concentrations (10−70 nM) of calmodulin. B: purified eNOS was incubated with decreasing (60–10 nM) calreticulin concentrations and increasing (10–60 nM) calmodulin concentrations, with 60 nM calreticulin alone, or with 60 nM calmodulin alone for 10 min at 37° C. After incubation, catalytic activity of eNOS was monitored. Values are mean ± SE; n= 6 for each data point. * p < 0.05 vs. 10−40 nM calmodulin alone (Reprinted from reference #52 with permission from the American Physiological Society).

From: Calreticulin Regulation of Lung Endothelial NOS Activity

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