[Table], Table 4. Studies of Cancer Treatment by Infection of Patients With NDVa - PDQ Cancer Information Summaries

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PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-.

PDQ Cancer Information Summaries [Internet].

Reference Citation(s)	Type of Study	NDV Strain	Type of Cancer	No. of Patients: Enrolled; Treated; Control^b	Strongest Benefit Reported^c	Concurrent Therapy^d	Level of Evidence Score^e
[39]	Phase II trial	MTH-68	Various advanced	59; 33; 26, placebo	Improved overall survival	No	2A
[44]	Phase I trial	PV701	Various advanced	79; 79; None	Partial tumor regression, 8 patients	Unknown	3iiiDiii
[46]	Phase I/II	HUJ	Glioblastoma multiforme, recurrent	14 (phase I–6; phase II–8); 11 (phase I–6, phase II–5); 0	1 transient (3 mo) complete response, all other patients had progressive disease	None	3iiiDiii
[38]	Case series	MTH-68	Various advanced	4; 4; None	Complete tumor regression, 2 patients	Yes	4
[47]	Selected case series	MTH-68/H	Gliomas, high-grade	4; 4; 0	Radiographically documented responses and long survival with improved symptomatology	Various	4Diii
[45]	Phase I	PV701	Various	16; 16; 0	Improved patient tolerability with two-step desensitization	None	N/A
[48]	Case report	MTH-68/H	Anaplastic astrocytoma	1; 1; 0	Partial response	Valproic acid	N/A
[40]	Case report	73-T	Advanced cervical	1; 1; None	Partial tumor regression	No	None
[41]	Anecdotal report	MTH-68	Various metastatic	3; 3; None	Tumor regression	Unknown	None
[42]	Case report	MTH-68	Glioblastoma multiforme	1; 1; None	Partial tumor regression	Yes	None
[43]	Case report	Hickman	Acute myeloid leukemia	1; 1; None	Partial response	Yes^f	None

: mo = month; No. = number.
: ^aRefer to text and the NCI Dictionary of Cancer Terms for additional information and definition of terms.
: ^bNumber of patients treated plus number of patients control may not equal number of patients enrolled; number of patients enrolled = number of patients initially recruited/considered by the researchers who conducted a study; number of patients treated = number of patients who were given the treatment being studied AND for whom results were reported; historical control subjects are not included in number of patients enrolled.
: ^cThe strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well being of cancer patients.
: ^dChemotherapy, radiation therapy, hormonal therapy, or cytokine therapy given/allowed at the same time as virus treatment.
: ^eFor information about levels of evidence analysis and an explanation of the level of evidence scores, refer to Levels of Evidence for Human Studies of Integrative, Alternative, and Complementary Therapies.
: ^fThis patient was treated with chemotherapy and five other types of virus in addition to NDV.

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PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Newcastle Disease Virus (PDQ®): Health Professional Version. 2018 Aug 22. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. [Table], Table 4. Studies of Cancer Treatment by Infection of Patients With NDVa.