Figure 3. Functional connection map of Abl kinases showing prospective upstream and downstream effectors that mediate cytoskeletal remodeling during cell migration.

Figure 3

Functional connection map of Abl kinases showing prospective upstream and downstream effectors that mediate cytoskeletal remodeling during cell migration. See references in schematic for details. Heregulin (HRG), EGF receptor family members ErbB2 and ErbB3 (ErbB2/3), hepatocyte growth factor receptor (Met), G-protein coupled receptors (GPCR), protein kinase A (PKA), Exchange factor directly activated by cAMP (Epac), α and β integrins receptors (αβ), extracellular matrix proteins (ECM), Focal adhesion kinase (FAK), platelet-derived growth factor receptor (PDGFR), Crk-associated substrate (CAS), CT10 regulator of kinase (Crk), Phospholipase C gamma one (PLC-γ1), Abelson tyrosine kinase (Abl), Abl-related gene (Arg), Abl interactor 1, 2 (Abi1/2), vasodilator-stimulated phosphoprotein (VASP), Wiskott-Aldrich syndrome protein (WASP), phosphatidyl inositol 4,5-bisphosphate (PIP2).

From: Regulation of Cell Motility by Abl Family Kinases

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.