Table 2-20(Normal reference range for TDP level 165–286 nmol/l)

The response of erythrocyte thiamine diphosphate (TDP) level
None (n=9)Oral (n=8)Parenteral (n=8)RR (95% CI)P value
Mean (± S.D.) Erythrocyte TDP (nmol/l)
Day 0 (pre-treatment)218 (± 29)218 (± 27)207 (± 47)Oral versus none: 0.00 (−26.63, 26.63)Oral versus none: 1.00
Parenteral versus none: −11.00 (−48.68, 26.68)Parenteral versus none: 0.57
Day 1 (post 250mg thiamine orally or parenterally)209 (± 39)265 (± 51)328 (± 117)Oral versus none: 56.00 (12.43, 99.57)Oral versus none: 0.01
Parenteral versus none: 119.00 (61.12, 176.88)Parenteral versus none: <0.001
Day 7 (post 5 × 250mg thiamine as above)220 (± 56)308 (± 64)298 (± 75)Oral versus none: 88.00 (30.51, 145.49)Oral versus none: 0.003
Parenteral versus none: 78.00 (14.44, 141.56)Parenteral versus none: 0.02
Change in mean after 250mg thiamin, or control−9+47+121--
Change in mean after 5 × 250mg thiamine or control+2+90+91--

From: 2, Acute Alcohol Withdrawal

Cover of Alcohol Use Disorders
Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet].
NICE Clinical Guidelines, No. 100.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guidelines Centre.

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