Table 2-13Summary of results

Medication dose
Study and OutcomePre versus Post pathwayP value
Pletcher 200552
% treated with diazepam49/188 (26%) versus 10/202 (5%)5.26; 2.25 to 10.09; p<0.00001
% treated with any benzodiazepine143/188 (77%) versus 152/202 (75%)1.01; 0.90 to 1.13; p=0.85
% treated with lorazepam120/188(64%) versus 131/202 (65%)0.98; 0.85 to 1.14; p=0.83
% treated with chloridazepoxide98/188 (52%)versus 91/202 (45%)1.16; 0.94 to 1.42; p=0.16
Repper-DeLisi 200850
% of benzodiazepine administered as standing doses
Days one, two and three
Approx
Day one 56 versus 75<0.05
Day two 62 versus 82<0.01
Day three 64 versus 80<0.05
Stanley 200751
% receiving drug therapy9/82 (11%) versus 36/106 (34%)RR0.32; 95%CI 0.17 to 0.63; p=0.001
<0.01
Mean total lorazepam mg (range)23.3 (0 to 186) versus 7.8 (0 to 58)<0.01
Mean total clonidine mg0.05 (0 to 1) versus 0.2 (0 to 6.6)0.17
Mean total haloperidol mg5.9 (0 to 129) versus 4.0 (0 to 106)RR4.74; 2.68 to 8.38; p<0.0001
% discharged on tapered benzodiazepine therapy44/82 versus 12/106
Wetterling 199714
% receiving clomethiazole64/132 (48%) versus 58/256 (23%)RR2.14; 1.61 to 2.85; p<0.0001
Mean amount of applied dose of clomethiazole per patients mg7680 (SD 8952) versus 5061 (2626)MD 2619; 1058 to 4179; p=0.001

From: 2, Acute Alcohol Withdrawal

Cover of Alcohol Use Disorders
Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet].
NICE Clinical Guidelines, No. 100.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guidelines Centre.

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