Figure 1. CtBP family proteins.

Figure 1

CtBP family proteins. A) Human CtBP1 isoforms. The splicing patterns of CtBP1 transcripts at the 5'- (exons 1 to 3) and 3'- (exon 9 and 10) regions are shown at the top. The intron-exon boundaries are based on NCBI ‘Spidey’ analysis of CtBP1 reference sequences for variant 1 (gi:61743965) and variant 2 (gi:12746589). The amino acid sequence variations at the N-terminal regions of CtBP1-L and CtBP1-S as well the polymorphic Ser residue (#380/369) are indicated. The domain structure of CtBP1-L is shown at the bottom. The phosphorylation sites by Pak1 and Hipk2, sumoylation site, PXDLS-binding region, and the PDZ-binding regions are indicated. The amino acid residues that constitute the catalytic triad of D2-HDH are indicated within filled circles. The amino acid sequence between residues 28 and 353 is highly conserved among animal CtBPs and D2-HDHs. B) Human CtBP2 isoforms. The domain structure of CtBP2 is shown at the top. The 5' regions of the two transcripts of the CtBP2 gene are shown at the bottom. The indicated splicing patterns (NCBI, Spidey) of the two transcripts are based on reference sequences, gi: 4557498 (variant 1) and gi:12746589 (variant 2). The two promoters of the CtBP2 gene are indicated as ‘Pro’. RE indicates RIBEYE. C) Domain structure of ANGUSTIFOLIA (AN) of Arabidopsis thaliana. The region of homology shared with animal CtBPs and D2-HDHs as well as other potential sequence motifs are indicated.

From: CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions

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